1255-1257 Cong LAJP 3386:Cong
نویسندگان
چکیده
Herb-drug interaction related with the drugs used to treat HIV patients was speculated in the present study. Therefore, zidovudine (AZT) was selected as an example, and in vitro incubation model was utilized to evaluate the inhibitory effect of herbal component methylophiopogonanone A towards the metabolism of AZT. The results showed the concentration-dependent inhibition of methylophiopogonanone A towards human liver microsomes (HLMs)-catalyzed AZT glucuronidation. Dixon plot and Lineweaver-Burk plot using the reaction velocity versus the concentrations of AZT and methylophiopogonanone A were performed to demonstrate the competitive inhibition of methylophiopogonanone A towards the glucuronidation of AZT. The inhibition kinetic parameter (Ki) value was calculated to be 87.8 μM. All these information indicated the necessary monitoring of clinical safety for the co-administration of AZT and methylophiopogonanone A-containing herbs.
منابع مشابه
1258-1262 Liu LAJP 3264:Liu
1 Department of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, 221002, Jiangsu, China 2 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu 221002, China 3 Environment Protection Research Institute of Xuzhou, Xuzhou, Jiangsu Province, China 4 Department of Anesthesia, Xuzhou Medical College, 84 West Huaihai Road, Xuzh...
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